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Paola Cipriani Selected Research

macitentan

10/2015The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist.
9/2015Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts.

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Paola Cipriani Research Topics

Disease

19Systemic Scleroderma (Systemic Sclerosis)
10/2022 - 01/2002
18Rheumatoid Arthritis
03/2021 - 06/2012
13Adult-Onset Still's Disease
07/2022 - 01/2014
11Fibrosis (Cirrhosis)
08/2019 - 01/2011
8Macrophage Activation Syndrome
10/2022 - 05/2015
8Arthritis (Polyarthritis)
10/2021 - 06/2012
7Inflammation (Inflammations)
10/2022 - 06/2007
7Autoimmune Diseases (Autoimmune Disease)
02/2021 - 05/2013
5Type 2 Diabetes Mellitus (MODY)
03/2021 - 06/2015
5Psoriatic Arthritis
01/2021 - 03/2013
5Infections
01/2020 - 11/2006
4Fever (Fevers)
10/2022 - 12/2016
4Exanthema (Rash)
10/2022 - 12/2016
4Rheumatic Diseases (Rheumatism)
01/2019 - 03/2014
3Fatigue
07/2022 - 08/2019
3Chronic Disease (Chronic Diseases)
07/2022 - 01/2021
3COVID-19
07/2022 - 01/2020
2Cytokine Release Syndrome
07/2022 - 04/2022
2Hyperferritinemia
07/2022 - 01/2020
2Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 01/2021
2Virus Diseases (Viral Diseases)
03/2021 - 01/2020
2Neoplasms (Cancer)
01/2021 - 08/2019
2Insulin Resistance
01/2021 - 02/2019
2Psoriasis (Pustulosis Palmaris et Plantaris)
11/2020 - 03/2013
2Hematologic Diseases (Blood Diseases)
01/2020 - 03/2009
2Pulmonary Arterial Hypertension
01/2020 - 01/2011
2Atherosclerosis
01/2019 - 06/2007
2Ankylosing Spondylitis
12/2018 - 01/2016
2Lymphadenopathy
01/2018 - 12/2016
2Lymphoma (Lymphomas)
01/2018 - 08/2015
2Hypertension (High Blood Pressure)
08/2017 - 01/2017
2Sialadenitis
11/2016 - 08/2015
2Vascular System Injuries
08/2016 - 08/2011
2Sjogren's Syndrome (Sjogren Syndrome)
08/2015 - 05/2013
1Lung Diseases (Lung Disease)
10/2022
1Arthralgia (Joint Pain)
10/2022
1Abdominal Pain (Pain, Abdominal)
10/2022
1Vascular Diseases (Vascular Disease)
10/2022
1Pain (Aches)
07/2022
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
07/2022
1Dermatomyositis (Dermatopolymyositis)
07/2022
1Septic Shock (Toxic Shock Syndrome)
07/2022
1Bites and Stings (Sting)
02/2022
1Axial Spondyloarthritis
01/2022
1Joint Diseases (Joint Disease)
02/2021
1Acquired Immunodeficiency Syndrome (AIDS)
02/2021
1Experimental Arthritis
01/2021
1Obesity
01/2021
1Splenomegaly
01/2021

Drug/Important Bio-Agent (IBA)

13CytokinesIBA
07/2022 - 03/2010
9Ferritins (Ferritin)IBA
10/2022 - 05/2015
6Biomarkers (Surrogate Marker)IBA
10/2022 - 01/2019
6Interleukin-1 (Interleukin 1)IBA
01/2020 - 06/2015
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2019 - 06/2012
5Biological ProductsIBA
03/2021 - 06/2015
5Tumor Necrosis Factor InhibitorsIBA
03/2021 - 06/2016
5InterleukinsIBA
03/2021 - 01/2015
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021 - 01/2002
4Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
03/2021 - 01/2019
4Pharmaceutical PreparationsIBA
02/2021 - 06/2012
4Antirheumatic Agents (DMARD)IBA
01/2020 - 12/2012
4EnzymesIBA
08/2019 - 05/2015
3Interleukin-10 (Interleukin 10)IBA
04/2022 - 07/2019
3C-Reactive ProteinIBA
01/2022 - 08/2017
3Interleukin-6 (Interleukin 6)IBA
01/2021 - 07/2015
3CollagenIBA
01/2021 - 06/2013
3SteroidsIBA
08/2019 - 12/2012
3Adrenal Cortex Hormones (Corticosteroids)IBA
04/2019 - 06/2016
3MicroRNAs (MicroRNA)IBA
01/2019 - 10/2018
2AntibodiesIBA
07/2022 - 12/2014
2InterferonsIBA
02/2022 - 03/2021
2Interleukin-17 (Interleukin 17)IBA
01/2021 - 01/2018
2Vitamin DFDA LinkGeneric
12/2020 - 07/2019
2tocilizumab (atlizumab)FDA Link
11/2020 - 01/2014
2AdipokinesIBA
02/2019 - 01/2018
2Glucose (Dextrose)FDA LinkGeneric
08/2017 - 01/2017
2Rituximab (Mabthera)FDA Link
11/2016 - 05/2013
2Chemokine CXCL12IBA
08/2016 - 09/2006
2Endothelin-1 (Endothelin 1)IBA
08/2016 - 10/2015
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2016 - 08/2011
2macitentanIBA
10/2015 - 09/2015
2Transforming Growth Factors (Transforming Growth Factor)IBA
10/2015 - 09/2015
2Interleukin-22 (IL-22)IBA
08/2015 - 05/2013
2Methotrexate (Mexate)FDA LinkGeneric
11/2014 - 03/2014
2Adalimumab (Humira)FDA Link
12/2012 - 06/2012
2Etanercept (Enbrel)FDA Link
12/2012 - 06/2012
2Infliximab (Remicade)FDA Link
12/2012 - 06/2012
1Acute-Phase Proteins (Acute-Phase Protein)IBA
10/2022
1ametantrone (HAQ)IBA
07/2022
1Phospholipids (Phosphatides)FDA LinkGeneric
07/2022
1Messenger RNA (mRNA)IBA
02/2022
1ChemokinesIBA
02/2021
1Rheumatoid FactorIBA
02/2021
1EpitopesIBA
02/2021

Therapy/Procedure

19Therapeutics
07/2022 - 01/2002
3Stem Cell Transplantation
11/2020 - 05/2013
2Immunomodulation
01/2020 - 03/2013
2Biological Therapy
02/2017 - 08/2011
1Precision Medicine
02/2021
1Ketogenic Diet
01/2021